Yildirim Cinar, A. Mete Senyol, Kamber Duman, Blood viscosity and you may blood circulation pressure: character off temperature and you can hyperglycemia, American Journal out of Blood pressure level, Volume fourteen, Material 5, , Pages 433–438,
Conceptual
We planned a study to research the relations among blood pressure (BP), viscosity, and temperature in healthy subjects and among BP, viscosity, and glucose in diabetics. With simple random sampling method, 53 healthy and 29 diabetes mellitus (DM) type II subjects were selected. Parameters were determined with capillary viscometer and glucometer at 22°C, 36.5°C, and 39.5°C in healthy subjects, and at 22°C on diabetic patients during OGTT with 75 g of glucose. Statistical evaluations of the data were made with regression analysis, Student t test, Spearman’s correlation, and analysis of variance. When temperature decreased from 36.5°C to 22°C, blood viscosity increased %. This increase resulted in a % decrease in blood flow rate. According to the Hagen-Poiseuille equation, the required BP increase for compensation of the resulting tissue ischemia was %. Also, a % decrease in erythrocyte deformability and % increase in plasma viscosity were seen. When temperature increased from 36.5° to 39.5°C, blood viscosity decreased %. This caused % decrease in blood flow rate, and % decrease in BP, according to the equation. Erythrocyte deformability increase of 9.92% and plasma viscosity decrease of 4.99% arose from the temperature rise. There is a correlation between total data for temperatures and viscosities (r = ?0.84, P < .001). When the mean value of blood glucose increased from 100 to 400 mg/dL, viscosity increased 25% (r = 0.59, P = .002). In this state, blood flow rate decrease was 20% and BP increase for physiological compensation was 25%. Consequently, temperature, glucose and viscosity levels of blood are important factors for BP. Am J Hypertens 2001;–438 © 2001 American Journal of Hypertension, Ltd.
The aim of our very own research will be to look into the relationship one of temperatures, sugar concentration, and you may viscosity out-of bloodstream and you can plasma, and determine the consequences for the blood pressure (BP) based on Hagen-Poiseuille’s hydrodynamics picture.
If the human circulatory system is considered as a closed system, hemodynamic equilibrium can be determined according to Poiseuille’s equation through the pressure, viscosity, flow rate, velocity of blood, and vessel diameter. Viscosity can be defined as the resistance of fluids against flow. The resistance for blood circulation includes friction between the blood elements and between the vessel lumen and blood. To make a fluid flow, the application of energy is required. Therefore, the energy of the circulatory system is spent in correlation with the viscosity level of blood. Energy forms of the circulatory system are BP and blood flow velocity. The velocity (v) and pressure of blood flow can be determined with Poiseuille’s equation as v = 1/4?L (F1 ? F2) (a 2 ? r 2 ), and also BP rate (Q) can be expressed from the above equation as Q = ?a 4 /8 local hookup app Oshawa ?L (F1 ? F2), where ? is the viscosity of the fluid, F1 and F2 are the initial and the final cross sectional pressures of blood, L is the length, a is the radius of vessel, and r is the distance from the center of the vessel for a flowing particle. 1, 2 Thus, to keep the equilibrium of the equation constant in the circulatory system, BP will increase when viscosity increases.
Bloodstream viscosity and you may blood pressure level: part away from temperatures and you may hyperglycemia
It’s been revealed one ranging from % and you can % viewpoints of hematocrit, most of the 11% rise in hematocrit develops bloodstream viscosity of the 20%. Within this state, considering Poiseuille’s picture, blood circulation speed reduces by the %, which could bring about tissues ischemia. To save the fresh circulatory system within the harmony (that’s, staying brand new move speed enough and you may stopping tissue ischemia), an excellent 20% rise in BP or 4.66% vasodilation will become necessary. 3 However, the human circulatory system is perhaps not an exact signed program, since the blood viscosity are going to be altered for the consumption out-of restaurants otherwise medicines. 4–8 Concurrently, the results regarding dietary fat and of particular pills for the bloodstream viscosity and you will hemodynamics such as for instance BP had been stated. Just like the atherosclerotic ships don’t dilate sufficiently once the a reaction to vasodilator drugs, this has been advised you to increased blood viscosity could only feel paid that have good BP upsurge in such products. 9–several Also, the fresh dating among BP, headache, coagulation, circulation acceleration, and you will bloodstream viscosity was in fact demonstrated via the standards off hemodynamics. thirteen, fourteen